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St. John's Wort
http://talentdevelop.com/articlelive/articles/698/1/St-Johns-Wort/Page1.html
HBC Protocols
HBC Protocols provides a wide variety of natural, science-based solutions to emotional health, depression, and aging concerns.  
By HBC Protocols
Published on 07/10/2007
 
St. John's wort's action of mood modulation takes place at the synapsomal level where it works to inhibit the reuptake of three of the four known feel-good neurotransmitters. They are serotonin, norepinephrine and dopamine.

Research-Grade St. John's Wort - from  HBCProtocols

St. John's wort's action of mood modulation takes place at the synapsomal level where it works to inhibit the reuptake of three of the four known feel-good neurotransmitters.

They are serotonin, norepinephrine and dopamine. Like many of the pharmaceuticals that inhibit the reuptake of only serotonin, this process can take up to 6 weeks to take effect.

SJW works more gently and broadly and given that it effects three neurotransmitters is probably why it has such a low side effect profile.

Also available: St. John's Wort Homeopathic Spray

See the HBC Protocols site for multiple summaries of Medical Studies on Hypericum and Depression
Scientific Description of Hypericum Perforatum
Studies Comparing Hypericum with Synthetic Drugs
Studies Comparing Hypericum with Placebos
 -- and many other Studies
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Evidence supports St. John's wort for depression treatment

The news on St. John's wort (sometimes touted as "nature's Prozac") appears to keep changing. Some studies suggest the herb is effective; others question its worth. But.. the bulk of evidence from ongoing studies suggests that the age-old remedy is a reliable mood elevator for people with mild to moderate depression.

Elena Conis, Los Angeles Times Health section, March 7, 2005